| Compounds | Topics | Title | Date |
|---|---|---|---|
| THC,CBD | cancer,colon cancer in vitro | Synthetic Cannabinoid Activity Against Colorectal Cancer Cells | Dec 2018 |
| In summary, we identified 10 synthetic cannabinoids demonstrating reproducible activity against human cells, with seven compounds reducing viability only in CRC cells. | |||
| cannabinoids | ibd,colon cancer in vitro | Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer | Feb 2019 |
| There is still a wide gap between preclinical evidence and the role of the ECS in human GI diseases. So far, little evidence exists whether cannabinoids are beneficial in human IBD and CRC, as large clinical trials are still missing. | |||
| cannabinoids | cancer,colon cancer in vitro | Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines. | Jan 2008 |
| The CB1 receptor can be considered an estrogen-responsive gene in DLD-1, HT-29 and SW620 cells. Up-regulation of CB1 expression by 17beta-estradiol is a further mechanism of estrogens to control colon cancer proliferation. | |||
| cannabinoids | cancer,colon cancer in vitro | Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells. | Dec 2008 |
|
Action Pathway: CB1,CB2 The present study shows that either CB1 or CB2 receptor activation induces apoptosis through ceramide de novo synthesis in colon cancer cells. Our data unveiled, for the first time, that TNF-alpha acts as a link between cannabinoid receptor activation and ceramide production. | |||
| CBD | cancer,colon cancer in vitro | Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer. | Aug 2012 |
| In colorectal carcinoma cell lines, cannabidiol protected DNA from oxidative damage, increased endocannabinoid levels and reduced cell proliferation in a CB(1)-, TRPV1- and PPARg-antagonists sensitive manner. It is concluded that cannabidiol exerts chemopreventive effect in vivo and reduces cell proliferation through multiple mechanisms. | |||
| CBG | colon cancer in vitro | Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid. | Dec 2014 |
| In vivo, CBG inhibited the growth of xenograft tumours as well as chemically induced colon carcinogenesis. CBG hampers colon cancer progression in vivo and selectively inhibits the growth of CRC cells, an effect shared by other TRPM8 antagonists. CBG should be considered translationally in CRC prevention and cure. | |||
| Caryophyllene | anti-oxidant,cancer,colon cancer in vitro | The Anticancer, anti-oxidant and Antimicrobial Properties of the Sesquiterpene Beta-Caryophyllene from the Essential Oil of Aquilaria crassna | Jun 2015 |
| beta--caryophyllene demonstrated potent inhibition against clonogenicity, migration, invasion and spheroid formation in colon cancer cells. These results prompt us to state that beta--caryophyllene is the active principle responsible for the selective anticancer and antimicrobial activities of A. crassnia. | |||
| CBD | cancer,colon cancer in vitro via experiment | Cannabidiol Enhances the Therapeutic Effects of TRAIL by Upregulating DR5 in Colorectal Cancer. | May 2019 |
|
Action Pathway: DR5 Positive Here, we found that the combination of cannabidiol and TNF-related apoptosis-inducing ligand (TRAIL) produces synergistic antitumor effects in vitro | |||